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KMID : 1143820150110020129
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Anxiety and Mood
2015 Volume.11 No. 2 p.129 ~ p.135
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Associations between Clinical Characteristics and Plasma BDNF Levels of Panic Disorder
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황인호:Hwang In-Ho
박종일:Park Jong-Il/양종철:Yang Jong-Chul
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Abstract
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Objective : Brain-derived neurotrophic factor (BDNF) is implicated in the pathophysiology of several neuropsychiatric disorders. However, there are few studies on BDNF of panic disorder. In this study, we investigated plasma BDNF levels in patients with panic disorder, and evaluated whether there are associations between clinical characteristics of panic disorder and plasma BDNF levels.
Methods : We included 110 patients with panic disorder and 110 health controls in the current study. Plasma BDNF levels were measured by the enzyme-linked immunosorbent assay (ELISA). Plasma BDNF level differences were evaluated according to the clinical characteristics, such as duration of illness, recent stressful life event, agoraphobia, and insomnia.
Results : The mean plasma BDNF levels of patients with panic disorder were significantly lower, as compared with those of controls (192.50 pg/mL vs. 693.75 pg/mL, t=8.838, p<0.001). The mean plasma BDNF levels of patients who had recent stressful life events were significantly higher, as compared with those who did not ( vs. , t=-2.525, p=0.013).
Conclusion : These results suggested that BDNF plays a potential role in the pathophysiology of panic disorder.
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KEYWORD
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BDNF, Neurotrophin, Panic disorder
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